pentobarbital will lower the level or impact of glecaprevir/pibrentasvir by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the level or result of estropipate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will reduce the level or result of roflumilast by affecting hepatic/